One hundred ten patients were prospectively randomized to chemotherapy consisting of cytoxan 750 mg m2 and Adriamycin 30 mg m2 on day 1 plus 5 fluorouracil 5 FU 500 mg m2 and methotrexate MTX, 40 mg m2 on day 8 versus the same chemotherapy plus tamoxifen 20 mg m2 on days 2 6 and premarin 0 priligy pills Cells growing in media containing insulin are less sensitive to inhibition by either tamoxifen or nafoxidine than are cells growing in its absence